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Istradefylline forty mg/day increased peak amounts and AUC of CYP3A4 substrates in clinical trials. This effect wasn't observed with istradefylline twenty mg/day. Look at dose reduction of delicate CYP3A4 substrates.Renal Impairment: Modafinil really should be employed with caution in patients with serious renal impairment. Having said that, no tip